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Topics:
Pediatric Hematology/Oncology • Medical Oncology • Internal Medicine • Thrombosis • Hematology • Pediatric Hematology • Benign Hematology • Hemostasis/Thrombosis
How do you manage VTE in the setting of persistent severe thrombocytopenia?
Is there a preferred strategy of transfusional support versus reduced-dose anticoagulation during the duration of thrombocytopenia?
Answer from: at Academic Institution
The thrombosis versus bleeding risk ratio should be weighed. The risk of VTE recurrence or propagation is highest in the first 30 days and we know that thrombocytopenia does not attenuate this risk. Providers should favor anticoagulation. In the case of cancer-associated thrombosis and chemotherapy-...
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Answer from: Medical Oncologist at Community Practice
Yes, with plt support (for transient thrombocytopenia). Plt threshold for transfusion at 50k.
Answer from: Medical Oncologist at Community Practice
It may be a good idea to estimate the risk of bleeding as well as the risk of further thrombosis. If thrombocytopenia is temporary, platelet transfusion and anticoagulation. If thrombocytopenia is going to last for a while and the count is expected to stay less than 50K, I would place a filter and h...