Please select the option that best describes you:
How long do you expect gastrointestinal side effects of leflunomide to persist after stopping treatment?
Answer from: at Academic Institution
Leflunomide (LEF) has a long half-lasting of about 15 days. So, when dealing with advise events such as gastrointestinal toxicity, these may persist up to several weeks following discontinuation of the drug.
Simply discontinuing LEF will prove to be effective in the majority of patients with advers...
Sign in or Register to read more
Answer from: at Academic Institution
Agree. However, it is difficult to adhere to a several-day regimen of cholestyramine for obvious reasons. In the original phase 3 RCTs, a single dose of cholestyramine was administered for intolerable/severe AEs, and these resolved very quickly, as a single dose reduces blood levels of LEF by approx...
Comments
at Arthritis Clinic of Central Texas
Simply put, a new onset, within a few weeks of sta...
Simply put, a new onset, within a few weeks of sta...
at Uniformed Services University of the Health Sciences (USUHS)
Fascinating about the one dose of cholestyramine l...
Fascinating about the one dose of cholestyramine l...
at Stanford University
It is not published, but was our experience during...
It is not published, but was our experience during...