How would you approach a locally advanced anorectal melanoma with local progression after 4 cycles of nivolumab and ipilimumab who is not a surgical candidate?

There is involvement of posterior vagina, left puborectalis, and peritoneal reflection. No nodes are involved.

Answer from: Radiation Oncologist at Community Practice

For non-operative management of anorectal melanoma, I most commonly use radiotherapy with a regimen of 30 Gy in 5 fractions delivered every other day vs twice weekly (Ballo et al., PMID 11958890; Kelly et al., PMID 21446049). The disease burden, in this case, sounds quite extensive in ...

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How would you approach a locally advanced anorectal melanoma with local progression after 4 cycles of nivolumab and ipilimumab who is not a surgical candidate?

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