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Topics:
Pediatric Hematology/Oncology • Medical Oncology • Internal Medicine • Hematology • Pediatric Hematology • Benign Hematology • Neutropenia
How would you approach moderate neutropenia (ANC < 1000) in a solid organ transplant recipient?
Is there a particular sequence you would adjust contributing antirejection or antimicrobial medications? Is the use of G-CSF appropriate and at what cutoff?
Answer from: at Academic Institution
There are limited data addressing the safety and efficacy of G-CSF in the solid-organ post-transplantation setting. Most case series report no increase in graft rejection with G-CSF treatment, although this question is not rigorously answered. Most cases of neutropenia in the post solid-organ transp...
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Answer from: at Community Practice
That is a very difficult question that depends on a lot of variables related to the transplant: which meds, degree of immunosuppression, risks of rejection, and others. It is best discussed with the patient's own transplant physicians.