How would you counsel a patient with extragenital lichens sclerosis on the acute and long term risks of post-lumpectomy radiotherapy?

Assume a mild but diffuse case of lichens sclerosis with involvement of the ipsilateral breast. If node negative disease, would you recommend she undergo mastectomy to avoid the potential for RT-related toxicity? If the decision is to treat with adjuvant RT, would you advise standard fractionation and/or partial breast irradiation?

Answer from: Radiation Oncologist at Community Practice

Lichen sclerosis (LS) is a rare entity, however, there are reports of successful treatment with radiation for various cancers associated with this condition. (Wang et al., PMID 33356763). There is also a suggestion of worse LC in women with vulvar cancer and preexisting LS (Fokdal et al., PMID ...

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Radiation Oncologist at Maimonides Medical Center
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How would you counsel a patient with extragenital lichens sclerosis on the acute and long term risks of post-lumpectomy radiotherapy?

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