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Radiation Oncology • Gynecologic Cancers • Endometrial Cancer • NCI-CCC Tumor Board Question • Johns Hopkins • NCI-CCC Gynecologic Tumor Board Question
How would you manage a clinically inoperable, stage IIIB, MMR deficient uterine cancer?
Tumor felt to be technically unresectable due to extensive cervical/parametrial involvement.
ER/PR and HER2 testing are pending.
Answer from: Radiation Oncologist at Academic Institution
Tough situation and uncommon case. If definitely inoperable, your options are to do preoperative systemic therapy or preoperative radiation therapy. I often advocate for preoperative radiation therapy as these tumors tend to respond well to radiation, and you can save the standard-of-care ...
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