How would you manage a T2N0 anal squamous cell carcinoma in a patient with a history of FAP s/p remote proctocolectomy with J pouch creation?  

This is a rare situation. The more common would be an adenocarcinoma developing in residual rectal mucosa after proctocolectomy for ulcerative colitis or FAP. If disease is locally advanced in those cases, and therefore an indication for radiotherapy, I’ve favored pre-op total neoadjuvant ther...