How would you sequence chemotherapy and radiotherapy for a patient with stage IIIC1 serous endometrial carcinoma?  

Definitions:CT-RT: Chemotherapy followed by radiation (+ synchronous chemotherapy)RT-CT: Radiation (+ synchronous chemotherapy) followed by chemotherapyCT-RT-CT: “Sandwich therapy”; chemotherapy, radiation, chemotherapyCT: ChemotherapyRT: Radiation therapyThe question raises two issues: ...

Adjuvant chemotherapy in advanced uterine serous carcinoma has been shown to improve survival. Radiation can be added for local control but my priority here would be the chemotherapy. HER2 is important to check (as you have) as the addition of trastuzumab (for her2 + tumors) in the upfront setting ...