How would you treat an elderly patient with biopsy proven extensive non-resectable metastatic pseudopapillary pancreatic tumor?  

This response is for cases that curative surgery or debulking surgery is not an option. These patients may respond to targeted therapy or hormonal therapy. We perform genomic profiling. If alterations are present which lead to the activation of PI3K/AKT/mTOR pathway, we use everolimus or temsirolimu...