How would you treat IIB ovarian carcinosarcoma which recurred locally at 1 month post initial debulking surgery, progressed through 2 cycles of adjuvant carbo/taxol, and is now s/p repeat debulking?  

Platinum refractory ovarian cancers are incredibly challenging. In terms of more conventional chemotherapy options and based on the AURELIA trial, one could consider bevacizumab in combination with pegylated liposomal doxorubicin or topotecan. I would not use paclitaxel since the cancer is progressi...

Also please consider a clinical trial for this patient; especially with HER2 targeted agent.