In rectal cancer patients receiving total neoadjuvant therapy, do you prefer chemotherapy followed by long-course chemoradiation, or short-course RT followed by chemotherapy?

Answer from: Radiation Oncologist at Academic Institution

We now have level 1 evidence showing the superiority of a few TNT regimens over standard chemoradiation->surgery->chemotherapy for these patients. There are going to be some stage II/III patients where TNT is overtreatment (ie, may be able to avoid the chemotherapy, radiation or surgery), but ...

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Radiation Oncologist at University of Cincinnati College of Medicine
Great summary @Parag J. Parikh! It will be interes...

Radiation Oncologist at Sanford Health
Does anybody have any input on quality of life? I ...

Radiation Oncologist at Henry Ford Health System
We have not seen a difference in long-term QOL bet...

Radiation Oncologist at Washington University School of Medicine
In IJROBP 88, 829-36, 2014, we mandated an interva...

Radiation Oncologist at Gulf International Cancer Center
Excellent thoughtful analysis by Dr. @Robert J. My...

Answer from: Radiation Oncologist at Community Practice

Any updates to this in light of recent data from RAPIDO regarding worse LC in SC?Dijkstra et al., PMID 36661037

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Medical Oncologist at Loyola University Chicago Stritch School of Medicine
Dr. @Simul Parikh had this same question and you c...

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In rectal cancer patients receiving total neoadjuvant therapy, do you prefer chemotherapy followed by long-course chemoradiation, or short-course RT followed by chemotherapy?

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