Is it acceptable to give weekly cisplatin for patients with locally advanced head and neck SCC undergoing chemoradiation?  

@Nabil F. Saba just presented at the ASCO H&N highlights session that weekly cisplatin 40mg/m2 is now considered a standard of care, at least in the post-op high risk setting based on data by Dr. Kiyota et al. showing superior outcomes, likely due to higher cumulative cisplatin dose (>200mg/m...

A number of chemotherapeutic agents have been utilized as radiation sensitizers during concomitant therapy. However, the most commonly used regimens include high-dose cisplatin (100 mg/m2 every 21 days for two or three doses), weekly cisplatin (30-40 mg/m2), weekly carboplatin (AUC=2) plus paclitaxe...

Recently published data suggests that weekly cisplatin 30 mg/m2 is inferior to high dose cisplatin (1). In a randomized phase III trial comparing high dose cisplatin at 100 mg/m2 to weekly cisplatin, weekly cisplatin resulted in a significantly higher risk of locoregional recurrence and a trend tow...