Is it ever acceptable to treat low pelvis (vs. whole pelvis) for an early vaginal recurrence of endometrial cancer?  

Retrospective data suggest pelvic RT helps but the volume of pelvic RT is variable as much of the data is in the 2D era. I usually treat common, external, and internal iliac in recurrent disease but would be reasonable to exclude common illiac node if morbidity is a concern.Vargo et al., PMID 252419...

In general, I agree with Dr. @Beriwal's answer. However, a case presented here is a very favorable recurrence disease. She had low-risk endometrial cancer before surgery and also a very small mucosal recurrence. I do not have data to support and experience but I wonder if small pelvic RT with HDR br...

I can't think of a specific case that I would consider treating low-pelvis (meaning not treating common iliac nodes to the level of the aortic bifurcation) for a vaginal recurrence of endometrial cancer. Perhaps someone with a significant history of IBD or other reasons to warrant toxicity concerns...