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Is there a maximum ifosfamide cumulative dose in patients with normal kidney function?   

When offering ifosfamide / etoposide for relapsed osteosarcoma, patient is being given 2.8mg/m2 of ifosfamide. Is 6-8 cycles exceeding any known lifetime dose limit? The increased number of cycles are given in the setting of high risk relapse (early/multifocal), after aggressive surgery, and having tolerated the first few cycles well.



Answer from: at Academic Institution
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at FibroFighters Foundation
Thank you!! Very helpful!!
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