What workup do you consider for a developmentally typical child with multiple large café au lait macules but no other signs of neurofibromatosis?  

The likelihood that this is NF1 depends somewhat in part on the age of the child in question. In infants and toddlers, cafe-au-lait macules are usually the first and only clinical sign of NF1. Most children with NF1 will develop skin fold freckling in early childhood, and the majority (probably 60-7...