Is there a role for prostate cancer lesion boost with EBRT in the setting of combination EBRT+ brachytherapy?  

In the setting of EBRT alone, a "FLAME"-style boost may increase bPFS. Does anyone have experience with increasing the EBRT dose in combination EBRT+LDR therapy for prostate cancer?

If an MRI and/or PSMA PET scan reveals a prostate lesion, is there a role for boosting the EBRT dose above 45 Gy/25fractions to the lesion in the setting of a planned Brachytherapy boost?

What constraints would you use for the bladder, urethra, and rectum?