Is there a role of definitive radiation or prostatectomy, in a patient who has M0 castrate resistant prostate cancer and whose PSA is undetectable on ADT and enzulatamide?  

The question posed comes from a rather unusual clinical situation. In most cases, M0 crpc would have evolved from a diagnosis of prostate cancer and the application of curative intent local therapy surgery/radiotherapy, with psa progression in the absence of metastatic disease managed with ADT now w...

There is a role for radiation to the primary site in men with low volume (oligometastatic) HSPC, based on recent data from STAMPEDE in 2019, which demonstrated a survival benefit in this subset of men, but no benefits to men with higher volume disease patterns of spread. This suggests that the prima...