Is there any role for direct oral anticoagulants in the treatment of antiphospholipid syndrome?  

Triple-negative APS is a confusing category as includes seronegative APS, APS with non-conforming aPL such as anti-phosphatidylserine-prothrombin amongst others, and the universe of patients with thrombotic events unrelated to antibody-mediated hypercoagulable state (eg Protein S, C or anti-thrombin...

There remains much uncertainty concerning the appropriate anticoagulation in an APS patient. I agree with most of the comments above. Of note, in these studies, particularly the study published in BLOOD, the vast majority of recurrent events were arterial. Likewise, although there is not a final rep...