Is there evidence to suggest that whole pelvic radiation is immunosuppressive and may lead to worse outcomes in the setting of chemoIO treatment for stage III endometrial cancer?

“Recent evidence” suggesting this was brought up in tumor board to justify excluding whole pelvic RT for a IIIC1 patient but I can’t find reference.

Answer from: Radiation Oncologist at Community Practice

There is data showing lymphopenia with pelvic RT but no outcome data showing it will have worse outcome with IO. Rather, a GOG study for concurrent chemo RT plus IO shows improvement in outcome in comparison to chemo RT alone leading to approval of the use of pembro for stage III and IVa cervical ca...

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Radiation Oncologist at Weill Cornell Medical College
Agree

Radiation Oncologist at Allegheny Health Network
GOG-3047/KEYNOTE-A18

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Is there evidence to suggest that whole pelvic radiation is immunosuppressive and may lead to worse outcomes in the setting of chemoIO treatment for stage III endometrial cancer?

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