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Gastrointestinal Cancers • Medical Oncology
Is there strong evidence to use TMB found in circulating tumor DNA to guide the use of ICI in metastatic colon cancer?
Answer from: Medical Oncologist at Academic Institution
The benefit of immunotherapy for patients with high TMB was demonstrated in the KEYNOTE 158 study (Marabelle et al., PMID 32919526). This is a phase 2 study that enrolled 1076 patients with advanced solid tumor (a total of 10 different tumor types including anal, biliary, cervical, endometrial, meso...
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Answer from: Medical Oncologist at Community Practice
Circulating tumor DNA has a consistently higher TMB than tissue. As noted by Dr. @Jin, MSKCC has demonstrated (Rousseau et al., PMID 33761214) no benefit for patients that are not MSI-H or POLE/POLD mutated (specific domain of polymerase also to generate the hypermutation phenotype) metastatic CRC p...