Should adjuvant maintenance chemotherapy be provided to children with anaplastic ependymoma following radiation therapy?  

We don't know yet, and this was the purpose of ACNS0831 (closed) and the rationale as well of the ongoing SIOP Ependymoma trial in Europe. In fact, the question is not whether we should offer chemotherapy to a child with anaplastic histology, as we know that anaplasia has very little meaning in this...