Should definitive concurrent chemoRT be offered to patients with anal canal SCCa with common iliac nodal involvement (by definition M1 disease) without evidence for other distant disease?

Very simply, the answer is yes. I would treat this patient aggressively. Nowadays we treat for cure many patients who have a formal M1 staging, and this patient fits into the same category. There is no clear answer as to how far proximal the nodal treatment should go, probably into the mid-paraaorti...

I agree with Joel's answer, the CI and PA nodes in anal cancer should be changed to N2. I typically treat up to the transverse duodenum in the case of CI involvement and up to the celiac axis for paraaortic involvement. We published in the Red J a small series showing that outcomes are similar to pe...