What are best practices in management of severe acute infusion reaction from infliximab?
Patient became acutely flushed, developed severe and prolonged hypotension with brief loss of consciousness, dizziness, nausea, dry heaves and headache. She had no chest pain, wheezing or lip/tongue swelling.
Answer from: at Academic Institution
Severe infusion reactions to infliximab are not typically IgE-mediated. The presumption is that it is ‘anaphylactoid’ due to IgG antibodies directed against the mouse chimeric proteins in the molecule. Stopping the infusion is essential (at least temporarily) and administering antihistam...
Comments
at Providence Thanks for this very useful answer. I use the seve...
Thanks for this very useful answer. I use the seve...