What cisplatin regimen do you prefer with adjuvant radiation in oropharyngeal SCC that is pT4N2 after surgery and bilateral neck dissection?  

Cisplatin 40 mg/m2 weekly.

If this cancer was HPV positive, perhaps the patient would have been better off not having surgery. 

Cisplatin-based chemoradiotherapy continues to be the standard. I personally use 100 mg/m2 every 3 weeks, since it’s the only regimen with randomized phase 3 data. However, I think there is likely no difference on the outcome when using 40 mg/m2 weekly in the adjuvant setting if the dose inten...