What is the best approach to treat a triple-negative inflammatory breast cancer with pCR following preoperative chemotherapy and a prior history of ipsilateral breast irradiation?

The patient was treated for left breast DCIS 5 years ago to a dose of 5040 cGy with a lumpectomy boost dose of 1600 cGy with conventional fractionation

Prior to chemotherapy for her new inflammatory TNBC, she had biopsy-proven matted axillary LN that were biopsy proven

Answer from: Radiation Oncologist at Academic Institution

Given inflammatory breast cancer recurrence, even with history of previous breast RT, I would offer reirradiation. Given DCIS, nodal irradiation would not have been used and the breast would be removed at mastectomy leaving chest wall. I would give dose of 50 Gy to CW and nodes, and I would use some...

Comments

Radiation Oncologist at Duke University Medical Center
Generally agree with Dr. @Chirag S. Shah's answer ...

Radiation Oncologist at Rush University Medical Center
Agree with the above but no boost. Pay attention t...

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What is the best approach to treat a triple-negative inflammatory breast cancer with pCR following preoperative chemotherapy and a prior history of ipsilateral breast irradiation?

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