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What is the evidence/rationale for not treating neuroblastoma metastatic sites which are MIBG negative after induction chemo?
What if there is residual soft tissue disease? Would you treat a distant metastatic site if only 1 or 2 metastatic sites total with gross residual after induction chemo but none are MIBG avid?
Answer from: Radiation Oncologist at Academic Institution
A clinically meaningful number of high-risk neuroblastoma patients are curable, which in part justifies metastasis-directed local therapy. It can be difficult though to balance the toxicity of multi-site irradiation with maximum control of sites of metastatic disease. Metastases that persist after i...
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