What is the optimal intrathecal chemotherapy regimen for leptomeningeal carcinomatosis from breast cancer?

What schedule do you use?

Answer from: Medical Oncologist at Academic Institution

For HER2- disease, we tend to do IT methotrexate or topotecan. For HER2+ disease, we routinely do IT Herceptin plus systemic treatments with a TKI like lapatinib with excellent long term control in some patients.

Comments

Medical Oncologist at Center for Hematology and Oncology
What schedule do you use for the methotrexate?

Medical Oncologist at H Lee Moffitt Cancer Center, University of South Florida
Usually, 15mg MTX IT with steroids every other day...

Medical Oncologist at University of Washington
IT or IV thiotepa is an option here, and some pati...

Medical Oncologist at Kettering Cancer Center
Is there a role of combining intrathecal trastuzum...

Medical Oncologist at H Lee Moffitt Cancer Center, University of South Florida
There are case reports of combining IT chemotherap...

Medical Oncologist at Cancer Care Specialists/Renown Oncology/UNR
For her2+, would you consider Tucatinib + IT Herce...

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What is the optimal intrathecal chemotherapy regimen for leptomeningeal carcinomatosis from breast cancer?

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