What is the preferred four-drug regimen for initial treatment of pan-susceptible tuberculous meningitis, given the need to achieve optimal CNS penetration?  

The recommended regimen is the same as for pulmonary TB, and most people are treated longer than for pulmonary TB. However, there are several things to consider given the concern for CNS penetration of drugs. Some experts increase the Rifampin dose to make it 20 mg/kg, not the usual 10 mg per kilog...