What is the preferred number of cycles of CAPOX for rectal cancer receiving total neoadjuvant chemotherapy?

The treatment of rectal cancer is probably more confusing than ever before!

The typical approach to “TNT” has been to give 4 months (8 cycles) of FOLFOX.

The optimal duration of Capox is less defined.

One reasonable option would be to aim for the same duration of 4 months. This would be ~5-6 cycles of ...

As with Dr. @Dr. First Last's excellent advice, I aim for 6 cycles of CAPOX in neoadjuvant therapy for advanced rectal cancer that I am treating with a TNT approach.

Similarly, I worry that we may be over-treating a not insignificant subset of patients with a universal TNT approach. As such, I typica...