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What is the radiation volume for M+ pure germinoma with brain only extra-ventricular mets and negative CSF/spine imaging?
Is chemotherapy recommended for M+ germinoma?
CR to chemo; Spine MRI negative; CSF negative
Is CSI required or whole brain radiation is sufficient for the initial phase?
What doses should be employed for each phase?
Answer from: Radiation Oncologist at Academic Institution
In general, I wouldn't recommend chemo for M+ Germinoma kids because it does not favorably improve the therapeutic ratio based on the findings from GCT96 (NCT00293358).Independent of chemo, 24 Gy CSI with a boost to 36-40Gy is sufficient for cure. With chemo, 21 Gy CSI & an involved field b...
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