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What is your local therapy paradigm for unresectable pelvic EWS cases?
Is there a role for dose escalation? Would you recommend sequential or SIB?
Is there more of a role for surgery vs. dose escalated RT in EWSR1-non-ETS rearrangements, non-EWSR1-ETS rearranged, CIC-rearranged, and BRCOR rearranged cases?
Answer from: Radiation Oncologist at Academic Institution
Unresectable pelvic Ewing sarcoma tumors are treated with definitive radiation therapy. The Children's Oncology Group local failure analysis of patients treated on INT-0091, INT-0154, and AEWS0031 demonstrated pelvic tumors treated with radiation therapy alone had a local failure incidence of 22.4% ...
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