Please select the option that best describes you:
Topics:
Internal Medicine • Infectious Disease • Pulmonology • Lung Transplant • Pulmonary Infections • Transplant Infectious Disease
What is your preferred agent for fungal prophylaxis in a patient post lung transplant with abnormal LFTs?
Do you consider isavuconazole to be less hepatotoxic than other azoles?
Answer from: at Academic Institution
Isavuconazonium tends to cause less elevations in LFTs.
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Answer from: at Academic Institution
Answer: Isavuconazole
Rationale:
Azole hepatotoxicity in my experience is ranked as following:
Voriconazole>Posaconazole>isavuconazole or itraconazole or fluconazole.
Therefore, my choice for lung transplant fungal prohylaxis is either itraconazole or isavuconazole if there is not pre-tran...