What neoadjuvant chemotherapy would you consider for squamous cell carcinoma arising from a ruptured tailgut cyst?  

Tailgut cysts are congenital lesions that develop from tailgut embryonic remnants. Though malignant transformation has been described, literature is largely limited to case reports. I would ensure the patient has been adequately staged with PET/CT and/or MRI of the pelvis. If resectable, I would adv...