What strategies have you found most effective for supporting weight loss in patients with bipolar disorder while minimizing the risk of mood destabilization?  

If residual depressive symptoms are present, then the addition of bupropion is helpful. If the weight gain is deemed due to necessary psychiatric medication, then the addition of metformin often works. Of course, for the management of weight, diet and exercise need to be encouraged (in addition to t...

I sometimes will add Topamax

I concur with the prior answers; in addition, in my practice when weight gain is a problem I strive to give advice about weight loss much more than just lip service.  I try to enlist the patient in making healthy body weight a priority, and go into detail about motivating the patient for health...

A healthy keto diet is my first recommendation but compliance with that is generally poor. GLP-1 agonists if you can hurdle the onerous PA process.  Agree with Topiramate...more effective at higher dosages 200-300mg/day and may provide additional mood stabilization.  

It would be very difficult to disagree with the above opinions.   We are the most obese nation on the planet, it seems...We also trying to repair most delicate and poorly understood condition like Bipolar disorder with a sledgehammer of our pills.It is very hard to not agree with a balance...

I don’t see any mention yet of use of GLP 1 RA meds. Anyone find one that works without (or with minimal risk) of manic switch?