What systemic therapy (FOLFOX or mFOLFIRINOX) would you use in T3 N1 M1 MMR proficient rectal cancer with solitary liver lesion when going for curative intent ( chemo --> short course RT --> resection of primary and liver met)?   

Hi,I think this is an important question. For resectable disease, most data we have is from the EORTC 40983 trial in which FOLFOX was used. For borderline resectable, you could consider FOLFOXIRI based on OLIVIA trial. That being said, obtaining molecular profiling for this patient is key which may ...

Assuming this is a resectable liver lesion, one may consider initial surgery for primary and metastatic focus with adjuvant chemotherapy. Radiation reduces local recurrence only which may not be high risk depending on the rectal lesion. If proceeding with the TNT approach, there is no compelling rea...

I agree with Drs. @Sahin and @Hochster that there is likely little to no benefit for using the more toxic FOLFOXIRI regimen over FOLFOX +/- biologic as appropriate. You could also argue for avoiding radiation therapy altogether if you have a sufficient response to FOLFOX in both the local ...