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Pediatric Hematology/Oncology • Medical Oncology • NCI-CCC Tumor Board Question • Germ Cell Tumors • AYA Tumor Board • Cleveland Clinic
What treatment regimen would you recommend for young adults with platinum refractory relapsed germ cell tumors?
Answer from: at Academic Institution
We assess the patient risk by IPFSG score, and if it is high score or has extragonadal primary site then we consider tandem high dose chemotherapy and autologous transplantation https://onlinelibrary.wiley.com/doi/full/10.1002/acg2.47
The data sometimes is unclear on the role of HDCT .
- the...
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Answer from: at Academic Institution
At USC, we use a Gemcitabine-based regimen (Gemcitabine/Oxaliplatin/Paclitaxel) similar to what has been described by Bokemeyer et al., PMID 18006893. We designed a dose-dense form of GOT, cycled every 14 days, with paclitaxel 170 mg/m2 on day 1 (as compared to 80 mg/m2). We escalate the oxaliplatin...