When do you consider using multiple antipsychotic medications for chronic management of psychosis?  

I've used multiple antipsychotics in three different types of scenarios: Finding a good benefit when you're in the middle of a cross-titration (e.g., cross-titrated olanzapine to ziprasidone due to sedation and weight gain; ziprasidone monotherapy was less effective, but adding back 5 mg olanzapi...

I use a second antipsychotic at times, mainly another generation for treatment-resistant hallucination and paranoia when clozapine is not an option for the patient (poor adherence to weekly blood draws). There is always a challenge to balance pros and cons, but at the end of the day, the quality of ...