When do you consider using setmelanotide for treatment of hypothalamic obesity?  

Setmelanotide is approved for people with rare monogenic forms of obesity (POMC, PCSK1 or LEPR deficiency) or Bardet Biedl Syndrome. I consider performing genetic testing in people with early onset of severe obesity and with uncontrollable hunger. I recommend sending these patients to an experienced...

Very rare condition and needs to be managed by somebody who sees many of this kind of pathologies. Familiarity with the treatment is very important.