When do you use seizure prophylaxis in patients on clozapine?  

The topic of the use of anticonvulsants for primary prophylaxis of clozapine-induced seizures continues to be debated. The idea of prescribing anticonvulsants prophylactically for patients taking >600 mg/day of clozapine was suggested by Devinksy et al., PMID 2006003 in 1991. Clozapine-induced se...

Congruent with Dr. @Thant and as recommended by Caetano, PMID 23996793, I based my decisions more on the clozapine level than on the dose per se. When prescribing an anticonvulsant, I tend to prescribe Lamotrigine (anticonvulsant doses 400-600 mg/day divided into two doses) due to favorable side eff...