Would the presence of multifocal LVSI change your adjuvant treatment recommendation for a surgically staged IA dedifferentiated endometrial carcinoma?  

Dedifferentiated is considered a high-grade lesion. There is admittedly low quality evidence on optimal management given lower incidence.I would recommend treatment with vaginal brachytherapy and very much offer chemotherapy. Would prefer vaginal brachytherapy, given the patient was surgically stage...

While a dedifferentiated Endometrial Cancer is a high grade lesion, in my opinion, it is not to be bundled in with high grade, Grade 3 endometrioid malignancies. A recent review by Goh et al., PMID 32090165, renewed their experience with 7 dedifferentiated malignancies. In this center, their OS for ...