Would you be willing to give definitive chemo-radiation and chemotherapy to a MSI-stable T2N0 low lying rectal cancer in a young healthy patient who wants to avoid surgery?

More likely to recommend total neoadjuvant therapy hoping for induction of complete clinical response. In our hands, on average, we are able to conserve the rectum in about 55% of treated patients with excellent rectal function and a regrowth rate of less than 10%. Local excision will not address th...

The question can be better stated as, "Would you be willing to give definitive chemoradiation to an MSI stable clinical stage cT2cN0 low lying rectal cancer in a young healthy patient who wants to avoid surgery?"

Since the clinical stage is used to direct decisions regarding the choice of primary tre...