Would you consider definitive concurrent chemoradiation to a patient with muscle invasive bladder cancer and a history of distal/sigmoid ulcerative colitis?  

Ulcerative colitis is a relative contraindication to radiotherapy, but not absolute, in my view. UC can have a spectrum of acuity as well, from distant/non-active to active-undertreatment. For many bladder cancer patients, radical cystectomy is the primary therapy +/- neoadjuvant or adjuvant chemot...