Would you consider using single agent oxaliplatin for adjuvant treatment for colon cancer in elderly patients who did not tolerate single agent 5-FU?  

I would not recommend that. To my knowledge, there have not been any adjuvant studies addressing this question; but we know from at least 2 older RCTs, that oxaliplatin monotherapy has little or no meaningful efficacy in patients with advanced disease, despite earlier single-arm studies suggesting e...