Would you offer additional adjuvant FOLFOX for patients with rectal CA undergoing TNT who transition to cape/RT and subsequent surgery early due to absence of clinical response to FOLFOX?

Given the number of treatment approaches to rectal cancer, it remains one of our biggest challenges in terms of extrapolating from the larger evidence base in colon cancer.

While the stage isn't given for the patient, let's assume they have a cT3N1 low rectal cancer and a TNT strategy is selected. If...