Would you prescribe ADT or AR inhibitors for a patient with moderate to severe dementia who has biochemical recurrent, non-metastatic prostate cancer, but otherwise good physical performance status and prognosis >5 years?   

I would discuss with their caregivers. They are the ones who have to manage the patient's moderate to severe dementia daily and presumably are acting as the patient's medical power of attorney. Practical consequences to typically routine therapies can be serious. Substantial declines in cognition, m...

At my institution, we are lucky to have a Geriatric Oncology group that provides pre-treatment assessment including life expectancy assuming no cancer diagnosis, and evaluation of comorbidities including optimization of medications or referrals for further management. I then use the MSKCC life expec...