Would you recommend chemoradiation to the pelvis for a patient with squamous cell carcinoma of the anus metastatic to the liver who has had a complete response to chemotherapy in the pelvis and a liver resection?  

The patient is very fortunate. Oligometastases in anal cancer is not a well-studied phenomenon. I do think that this patient is at risk of recurrence in the pelvis, which could be very symptomatic. For this reason, I would suggest radiation therapy. And probably at doses used in the early days of tr...

We know from RTOG 98-11 that preceding definitive RT for anal cancer with two cycles of neoadjuvant 5FU/Platinum degrades the colostomy free survival. Avoiding neoadjuvent chemo and giving RT with concurrent 5FU/MMC up front means that the radiation is sensitized by full doses of concurrent chemothe...