Would you skip adjuvant RT in post prostatectomy patients?   

I suspect that once the paper is published and we get a chance to review the data that we may begin to hold off on routine use of adjuvant RT for prostate cancer patients after radical prostatectomy with higher risk features. That said, it should be noted that the study did randomize to early salvag...

I have always leaned to early salvage RT, as opposed to direct post-op RT, because prostate bed RT is not always such a "benign" undertaking, and so I like to be convinced that it is absolutely necessary. This study does not change that opinion. That said, I do continue to be amazed at how frequentl...

Would just like to add in that RAVES presented at ASTRO 2019 had more classical, at least for US Rad Oncs, inclusion criteria and showed essentially the same findings as RADICALS: Early salvage, without ADT, seems equivalent to adjuvant. Others above have mentioned the caveats on actually doing 'ear...

As many have pointed out one problem with Radicals-RT is the patient population they enrolled. "Patients with post-op PSA≤0.2ng/ml and ≥1 risk factor (pT3/4, Gleason 7-10, positive margins or pre-op PSA≥10ng/ml) were randomized" Who was going to expect benefit from adjuvant RT in a patien...

I agree with Dr. Sandler as well.  I am very interested to see the breakdown by Gleason score and further details in the manuscript of the Radicals trial.  From the presentation, only 17%/16 % of pts had Gleason 8 or greater disease and >50% had 6 or 3+4=7.  With a median f/u of...

A non-rising low level PSA following radical prostatectomy may indicate surgical sparing of a portion of the seminal vesicles and thus would not benefit from radiation.