Are there any concerns utilizing apremilast for psoriatic arthritis in patients who are also taking roflumilast for COPD?  

This is an interesting question which I don't have a good answer for. In my experience, I have not used the combination and upon my review of the literature, I did not find any reported use of the combination. Roflumilast is currently being studied in and shows efficacy in psoriasis both in topical ...