Are there any known contraindications for IL-23 use in patients with psoriatic arthritis and CKD or ESRD?  

There are no contraindications in the use of IL-23 inhibitors in the treatment of psoriatic arthritis. The package insert suggests no dosage adjustments for CKD. Clearance of a monoclonal ab is through degradation to small peptides and amino acids in a fashion similar to endogenous IgG. My only conc...