Sarcoidosis   

Do you use TNF-i or MMF?

Patient with mild cytopenias, but not requiring transfusions and no infection issues. Non-caseating granulomas on bone marrow biopsy. 

Patient with a history of presumed benign ethnic neutropenia: PMN 1.5 prior to azathioprine and 1.2 after starting. The patient has an intolerance to ...

Is there any utility in ACE levels and/or IL-2 levels in the diagnostic work-up of cardiac sarcoidosis? 

Pre-treatment troponin was mildly elevated, while ILR2 receptor, ACE, CRP, ESR were normal. 

If not, are there any serum or CSF tests you consider to be helpful?

Is a biopsy or EMG helpful in confirming the etiology? What is the best treatment for sarcoid neuropathy?

Specifically, do you check for any of these: ACE, Vitamin D 1,25, serum lysozyme, soluble IL2 or Adenosine deaminase levels?

Patient with alcoholism referred to rheumatology for elevated ACE level in the setting of new onset mild sensory peripheral neuropathy on nerve conduc...

Would you use with DMARDs/biologics or monitor?

Do you use biomarkers or PET scanning to stratify patients who may benefit most from therapy?

Do you obtain serial cardiac PET scans?

Do you typically push for myocardial biopsy in this case? 

Lymph node biopsy with non-caseating granulomas and other etiologies (malignancy, infection, vasculitis) ruled out. 

Multiple lesions on PET